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SARS-CoV-2 variants, immune escape, and countermeasures

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 196-207 doi: 10.1007/s11684-021-0906-x

Abstract: Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully

Keywords： SARS-CoV-2     COVID-19     vaccine     immune escape     breakthrough     prevention    

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: pri-OPC-like tumors showed substantially down-regulated MHC-I genes, suggesting their distinct immuneSome specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytesTheir expression was positively correlated with those of immune checkpoint genes (e.g., LGALS3a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneHowever, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers.Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immuneIn this work, the author focuses on the combination therapy of multiple immune checkpoints (does not

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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identification, and clinical application of anti-HBs monoclonal antibody that binds both wild-type and immuneescape mutant HBsAgs

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 277-283 doi: 10.1007/s11684-009-0047-0

Abstract: anti-HBs antibody, we developed a sandwich ELISA (defined G6m ELISA) for detecting both wild-type and immuneescape mutant HBsAgs (IEM HBsAg).

Keywords： hepatitis B virus     gene variation     hepatitis B surface antigen     immune escape     enzyme-linked immunosorbent    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Research on pedestrian escape route without visibility based on Markov chain model

Xiaoping ZHENG, Lijuan DU, Hongjiang WANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 283-289 doi: 10.1007/s11705-009-0272-8

Abstract: It is a pioneering work to use a Markov chain model to study the pedestrian escape route without visibilityMarkov chain probability transition matrix, the algorithms with random numbers and the spatial-grid, an escapeAt the same time, this paper analyzes the escape route from two views, i.e., pedestrian pace states andresearch results show that the Markov chain model is more realistic as a means of studying pedestrian escape

Keywords： pioneering     direction     spatial-grid     realistic     transition characteristic    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 773-783 doi: 10.1007/s11684-021-0902-1

Abstract: The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitorspatients with eligibility and response to ICIs based on the 2015 Chinese cancer statistics and the immune

Keywords： benefit     China     eligibility     immune checkpoint inhibitor     public health    

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theadaptive immune system.In the innate immune system, the interactions between pathogen-associated molecular patterns and hostMacrophages, dendritic cells, and natural killer cells are the principal innate immune components thatThis knowledge provides an enhanced understanding of the innate immune response to RNA viral infections

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 24-31 doi: 10.1007/s11684-019-0679-7

Abstract: Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advancedHowever, not all patients are responsive to immune checkpoint inhibitors.The response rate depends on the immune microenvironment, tumor mutational burden (TMB), expression levelof immune checkpoint proteins, and molecular subtypes of cancers.provide large volumes of data, which allow researchers to explore responsive or resistant biomarkers of immune

Keywords： immune checkpoint blockade     sensitivity     resistance     data mining    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitsthe activation of immune cells through the interaction with its ligand CD24 on tumor cells.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Title Author Date Type Operation

SARS-CoV-2 variants, immune escape, and countermeasures

Journal Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

identification, and clinical application of anti-HBs monoclonal antibody that binds both wild-type and immuneescape mutant HBsAgs

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Research on pedestrian escape route without visibility based on Markov chain model

Xiaoping ZHENG, Lijuan DU, Hongjiang WANG,

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

Journal Article

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article